Cargando…

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

A major problem for cancer patients is the metastasis of cancer cells from the primary tumor. This involves: (1) migration through the basement membrane; (2) dissemination via the circulatory system; and (3) invasion into a secondary site. Metastasis suppressors, by definition, inhibit metastasis at...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Wensheng, Kovacevic, Zaklina, Peng, Zhihai, Jin, Runsen, Wang, Puxiongzhi, Yue, Fei, Zheng, Minhua, Huang, Michael L-H., Jansson, Patric J., Richardson, Vera, Kalinowski, Danuta S., Lane, Darius J.R., Merlot, Angelica M., Sahni, Sumit, Richardson, Des R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742122/ https://www.ncbi.nlm.nih.gov/pubmed/26431493

Ejemplares similares

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1
por: Liu, Wensheng, et al.
Publicado: (2015)

Targeting cancer by binding iron: Dissecting cellular signaling pathways
por: Lui, Goldie Y.L., et al.
Publicado: (2015)

Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1
por: Geleta, Bekesho, et al.
Publicado: (2022)

Letter to the Editor: “Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques”
por: Merlot, Angelica M., et al.
Publicado: (2016)

Copper that cancer with lysosomal love!
por: Kovacevic, Zaklina, et al.
Publicado: (2016)

Duodenal Cytochrome b (DCYTB) in Iron Metabolism: An Update on Function and Regulation
por: Lane, Darius J. R., et al.
Publicado: (2015)

Unraveling the mysteries of serum albumin—more than just a serum protein
por: Merlot, Angelica M., et al.
Publicado: (2014)

IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE
por: KRISHAN, SUKRITI, et al.
Publicado: (2015)

The metastasis suppressor, NDRG1, inhibits “stemness” of colorectal cancer via down-regulation of nuclear β-catenin and CD44
por: Wangpu, Xiongzhi, et al.
Publicado: (2015)

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells
por: Merlot, Angelica M., et al.
Publicado: (2015)

The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer
por: Lim, Syer C., et al.
Publicado: (2021)

N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion
por: Lane, Darius J. R., et al.
Publicado: (2013)

Correction: N-myc Downstream Regulated 1 (NDRG1) Is Regulated by Eukaryotic Initiation Factor 3a (eIF3a) during Cellular Stress Caused by Iron Depletion
por: Lane, Darius J. R., et al.
Publicado: (2016)

Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly
por: Lane, Darius J. R., et al.
Publicado: (2016)

Differential targeting of the cyclin-dependent kinase inhibitor, p21(CIP1/WAF1), by chelators with anti-proliferative activity in a range of tumor cell-types
por: Moussa, Rayan S., et al.
Publicado: (2015)

The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms
por: Guo, Zhu-Ling, et al.
Publicado: (2016)

PGRMC1 regulation by phosphorylation: potential new insights in controlling biological activity!
por: Cahill, Michael A., et al.
Publicado: (2016)

The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis
por: Huang, Michael L.-H., et al.
Publicado: (2019)

Investigating the Spectrum of Biological Activity of Ring-Substituted Salicylanilides and Carbamoylphenylcarbamates
por: Otevrel, Jan, et al.
Publicado: (2010)

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC
por: Seebacher, Nicole A, et al.
Publicado: (2016)

Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
por: Chang, Jiawei, et al.
Publicado: (2023)

Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers
por: Abd El-Aziz, Yomna S., et al.
Publicado: (2021)

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites
por: Potůčková, Eliška, et al.
Publicado: (2015)

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma
por: Abd El-Aziz, Yomna S., et al.
Publicado: (2021)

Src Regulates the Activity of the ING1 Tumor Suppressor
por: Yu, Lisa, et al.
Publicado: (2013)

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
por: Zhang, Jia, et al.
Publicado: (2017)

Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis
por: Sirvent, Audrey, et al.
Publicado: (2020)

AGO2 phosphorylation by c-Src kinase promotes tumorigenesis
por: Liu, Tianqi, et al.
Publicado: (2020)

Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids
por: Filak, Lukas K., et al.
Publicado: (2014)

CXCR7 promotes melanoma tumorigenesis via Src kinase signaling
por: Xu, Siran, et al.
Publicado: (2019)

Modelling Cooperative Tumorigenesis in Drosophila
por: Richardson, Helena E., et al.
Publicado: (2018)

Quantitative Analysis of the Anti-Proliferative Activity of Combinations of Selected Iron-Chelating Agents and Clinically Used Anti-Neoplastic Drugs
por: Potuckova, Eliska, et al.
Publicado: (2014)

Structure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties
por: Potůčková, Eliška, et al.
Publicado: (2014)

Siderocalin/Lcn2/NGAL/24p3 Does Not Drive Apoptosis Through Gentisic Acid Mediated Iron Withdrawal in Hematopoietic Cell Lines
por: Correnti, Colin, et al.
Publicado: (2012)

The Metastasis Suppressor, N-myc Downregulated Gene 1 (NDRG1), Is a Prognostic Biomarker for Human Colorectal Cancer
por: Mao, Zhihai, et al.
Publicado: (2013)

Src-mediated phosphorylation converts FHL1 from tumor suppressor to tumor promoter
por: Wang, Xiang, et al.
Publicado: (2018)

Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis
por: Matozaki, Takashi, et al.
Publicado: (2020)

Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis
por: Lagopati, Nefeli, et al.
Publicado: (2021)

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target
por: Gillson, Josef, et al.
Publicado: (2022)

Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colon
por: Xiao, Juanjuan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_l71u0j1qonmo8jbj7b9laqam23