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Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis

A section of gastric cancers presents nuclear β-catenin accumulation correlated with H. pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and epidermal growth factor receptor (EGFR), or by inhibiting tumor suppressor Runx3 and Trefoil factor 1 (TFF1). H. pylor...

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Detalles Bibliográficos
Autores principales: Song, Xiaowen, Xin, Na, Wang, Wei, Zhao, Chenghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742126/
https://www.ncbi.nlm.nih.gov/pubmed/26417932
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author Song, Xiaowen
Xin, Na
Wang, Wei
Zhao, Chenghai
author_facet Song, Xiaowen
Xin, Na
Wang, Wei
Zhao, Chenghai
author_sort Song, Xiaowen
collection PubMed
description A section of gastric cancers presents nuclear β-catenin accumulation correlated with H. pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and epidermal growth factor receptor (EGFR), or by inhibiting tumor suppressor Runx3 and Trefoil factor 1 (TFF1). H. pylori also trigger Wnt/β-catenin pathway by recruiting macrophages. Moreover, Wnt/β-catenin pathway is found involved in H. pylori-induced gastric cancer stem cell generation. Recently, by using gastroids, researchers have further revealed that H. pylori induce gastric epithelial cell proliferation through β-catenin. These findings indicate that Wnt/β-catenin is an oncogenic pathway activated by H. pylori. Therefore, this pathway is a potential therapy target for H. pylori-related gastric cancer.
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spelling pubmed-47421262016-04-04 Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis Song, Xiaowen Xin, Na Wang, Wei Zhao, Chenghai Oncotarget Review A section of gastric cancers presents nuclear β-catenin accumulation correlated with H. pylori infection. H. pylori stimulate Wnt/β-catenin pathway by activating oncogenic c-Met and epidermal growth factor receptor (EGFR), or by inhibiting tumor suppressor Runx3 and Trefoil factor 1 (TFF1). H. pylori also trigger Wnt/β-catenin pathway by recruiting macrophages. Moreover, Wnt/β-catenin pathway is found involved in H. pylori-induced gastric cancer stem cell generation. Recently, by using gastroids, researchers have further revealed that H. pylori induce gastric epithelial cell proliferation through β-catenin. These findings indicate that Wnt/β-catenin is an oncogenic pathway activated by H. pylori. Therefore, this pathway is a potential therapy target for H. pylori-related gastric cancer. Impact Journals LLC 2015-09-21 /pmc/articles/PMC4742126/ /pubmed/26417932 Text en Copyright: © 2015 Song et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Song, Xiaowen
Xin, Na
Wang, Wei
Zhao, Chenghai
Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title_full Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title_fullStr Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title_full_unstemmed Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title_short Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis
title_sort wnt/β-catenin, an oncogenic pathway targeted by h. pylori in gastric carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742126/
https://www.ncbi.nlm.nih.gov/pubmed/26417932
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