A newly identified berberine derivative induces cancer cell senescence by stabilizing endogenous G-quadruplexes and sparking a DNA damage response at the telomere region

The guanine-rich sequences are able to fold into G-quadruplexes in living cells, making these structures promising anti-cancer drug targets. In the current study, we identified a small molecule, Ber8, from a series of 9-substituted berberine derivatives and found that it could induce acute cell grow...

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Detalles Bibliográficos
Autores principales: Xiong, Yun-Xia, Su, Hua-Fei, Lv, Peng, Ma, Yan, Wang, Shi-Ke, Miao, Hui, Liu, Hui-Yun, Tan, Jia-Heng, Ou, Tian-Miao, Gu, Lian-Quan, Huang, Zhi-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742130/
https://www.ncbi.nlm.nih.gov/pubmed/26462146

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