Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity

In human SH-SY5Y neuroblastoma (NB) cells, nascent immature N-glycosylated 110kDa TrkA moves rapidly from the endoplasmic reticulum (ER) to the Golgi Network (GN), where it matures into the 140kDa receptor prior to being transported to the cell surface, creating GN and cell surface pools of inactive...

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Detalles Bibliográficos
Autores principales: Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Maccarone, Rita, Mackay, Andrew Reay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742131/
https://www.ncbi.nlm.nih.gov/pubmed/26415233

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