Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition

Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synt...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, John Paul, Srivas, Rohith, Gross, Andrew, Li, Jianfeng, Jaehnig, Eric J., Sun, Su Ming, Bojorquez-Gomez, Ana, Licon, Katherine, Sivaganesh, Vignesh, Xu, Jia L., Klepper, Kristin, Yeerna, Huwate, Pekin, Daniel, Qiu, Chu Ping, van Attikum, Haico, Sobol, Robert W., Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742139/
https://www.ncbi.nlm.nih.gov/pubmed/26437225

Ejemplares similares

Ejemplares similares