Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney

Here we showed that dietary NiCl(2) in excess of 300 mg/kg caused the G(2)/M cell cycle arrest and the reduction of cell proportion at S phase. The G(2)/M cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-ATM), p53, p-Chk1, p-Chk2, p21 protein expr...

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Autores principales: Guo, Hongrui, Cui, Hengmin, Peng, Xi, Fang, Jing, Zuo, Zhicai, Deng, Junliang, Wang, Xun, Wu, Bangyuan, Chen, Kejie, Deng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742154/
https://www.ncbi.nlm.nih.gov/pubmed/26440151
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author Guo, Hongrui
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
Chen, Kejie
Deng, Jie
author_facet Guo, Hongrui
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
Chen, Kejie
Deng, Jie
author_sort Guo, Hongrui
collection PubMed
description Here we showed that dietary NiCl(2) in excess of 300 mg/kg caused the G(2)/M cell cycle arrest and the reduction of cell proportion at S phase. The G(2)/M cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-ATM), p53, p-Chk1, p-Chk2, p21 protein expression and ATM, p53, p21, Chk1, Chk2 mRNA expression, and down-regulation of p-cdc25C, cdc2, cyclinB and proliferating cell nuclear antigen (PCNA) protein expression and the cdc25, cdc2, cyclinB, PCNA mRNA expression.
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spelling pubmed-47421542016-04-04 Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney Guo, Hongrui Cui, Hengmin Peng, Xi Fang, Jing Zuo, Zhicai Deng, Junliang Wang, Xun Wu, Bangyuan Chen, Kejie Deng, Jie Oncotarget Research Paper Here we showed that dietary NiCl(2) in excess of 300 mg/kg caused the G(2)/M cell cycle arrest and the reduction of cell proportion at S phase. The G(2)/M cell cycle arrest was accompanied by up-regulation of phosphorylated ataxia telangiectasia mutated (p-ATM), p53, p-Chk1, p-Chk2, p21 protein expression and ATM, p53, p21, Chk1, Chk2 mRNA expression, and down-regulation of p-cdc25C, cdc2, cyclinB and proliferating cell nuclear antigen (PCNA) protein expression and the cdc25, cdc2, cyclinB, PCNA mRNA expression. Impact Journals LLC 2015-09-30 /pmc/articles/PMC4742154/ /pubmed/26440151 Text en Copyright: © 2015 Guo et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Guo, Hongrui
Cui, Hengmin
Peng, Xi
Fang, Jing
Zuo, Zhicai
Deng, Junliang
Wang, Xun
Wu, Bangyuan
Chen, Kejie
Deng, Jie
Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title_full Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title_fullStr Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title_full_unstemmed Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title_short Dietary NiCl(2) causes G(2)/M cell cycle arrest in the broiler's kidney
title_sort dietary nicl(2) causes g(2)/m cell cycle arrest in the broiler's kidney
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742154/
https://www.ncbi.nlm.nih.gov/pubmed/26440151
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