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Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1

BACKGROUND: The mitochondrial accumulation of ATF2 is involved in tumor suppressor activities via cytochrome c release in melanoma cells. However, the signaling pathways that connect mitochondrial ATF2 accumulation and cytochrome c release are not well documented. METHODS: Several melanoma cell line...

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Detalles Bibliográficos
Autores principales:	Gao, Zongwei, Shang, Qingjuan, Liu, Zhaoyun, Deng, Chun, Guo, Chunbao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742181/ https://www.ncbi.nlm.nih.gov/pubmed/26462148

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