mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer

We investigated the effects of mTOR and MEK1/2 inhibition on tumor growth and the tumor microenvironment in immunogenic and poorly immunogenic models of murine oral cancer. In vitro, rapamycin and PD901 inhibited signaling through expected downstream targets, but only PD901 reduced viability and alt...

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Detalles Bibliográficos
Autores principales: Cash, Harrison, Shah, Sujay, Moore, Ellen, Caruso, Andria, Uppaluri, Ravindra, Van Waes, Carter, Allen, Clint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742185/
https://www.ncbi.nlm.nih.gov/pubmed/26506415

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