Auranofin induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with piperlongumine in gastric cancer

Gastric cancer (GC) is one of the leading causes of cancer mortality in the world. In addressing the need of treatments for relapsed disease, we report the identification of an existing U.S. Food and Drug Administration-approved small-molecule drug to repurpose for GC treatment. Auranofin (AF), clin...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Peng, Chen, Minxiao, Ji, Jiansong, Chen, Weiqian, Chen, Xi, Ying, Shilong, Zhang, Junru, Zhang, Ziheng, Liu, Zhiguo, Yang, Shulin, Liang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742192/
https://www.ncbi.nlm.nih.gov/pubmed/26431378

Ejemplares similares

Ejemplares similares