Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway

Overexpression of the transcriptional factor Hes1 (hairy and enhancer of split-1) has been observed in numerous cancers, but the precise roles of Hes1 in epithelial-mesenchymal transition (EMT), cancer invasion and metastasis remain unknown. Our current study firstly revealed that Hes1 upregulation...

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Detalles Bibliográficos
Autores principales: Wang, Sheng-Chun, Lin, Xiao-Lin, Wang, Hui-Yan, Qin, Yu-Juan, Chen, Lin, Li, Jing, Jia, Jun-Shuang, Shen, Hong-Fen, Yang, Sheng, Xie, Rao-Ying, Wei, Fang, Gao, Fei, Rong, Xiao-Xiang, Yang, Jie, Zhao, Wen-Tao, Zhang, Ting-Ting, Shi, Jun-Wen, Yao, Kai-Tai, Luo, Wei-Ren, Sun, Yan, Xiao, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742206/
https://www.ncbi.nlm.nih.gov/pubmed/26452025

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