Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in gorlin syndrome

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder that is due, in large measure, to aberrant Shh signaling driven by mutations in the tumor suppressor gene Ptch1. Here, we describe the development of Ptch1(+/−)/SKH-1 mice as a novel model of this disease. These anima...

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Detalles Bibliográficos
Autores principales: Chaudhary, Sandeep C., Tang, Xiuwei, Arumugam, Aadithya, Li, Changzhao, Srivastava, Ritesh K., Weng, Zhiping, Xu, Jianmin, Zhang, Xiao, Kim, Arianna L., McKay, Kristopher, Elmets, Craig A., Kopelovich, Levy, Bickers, David R., Athar, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742211/
https://www.ncbi.nlm.nih.gov/pubmed/26413810

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