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Discovery of Novel Hepatitis C Virus NS5B Polymerase Inhibitors by Combining Random Forest, Multiple e-Pharmacophore Modeling and Docking

The NS5B polymerase is one of the most attractive targets for developing new drugs to block Hepatitis C virus (HCV) infection. We describe the discovery of novel potent HCV NS5B polymerase inhibitors by employing a virtual screening (VS) approach, which is based on random forest (RB-VS), e-pharmacop...

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Detalles Bibliográficos
Autores principales:	Wei, Yu, Li, Jinlong, Qing, Jie, Huang, Mingjie, Wu, Ming, Gao, Fenghua, Li, Dongmei, Hong, Zhangyong, Kong, Lingbao, Huang, Weiqiang, Lin, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742222/ https://www.ncbi.nlm.nih.gov/pubmed/26845440 http://dx.doi.org/10.1371/journal.pone.0148181

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