Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases

tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer...

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Detalles Bibliográficos
Autores principales: Fu, Yu, Lee, Inhan, Lee, Yong Sun, Bao, Xiaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742329/
https://www.ncbi.nlm.nih.gov/pubmed/26865839
http://dx.doi.org/10.5808/GI.2015.13.4.94
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author Fu, Yu
Lee, Inhan
Lee, Yong Sun
Bao, Xiaoyong
author_facet Fu, Yu
Lee, Inhan
Lee, Yong Sun
Bao, Xiaoyong
author_sort Fu, Yu
collection PubMed
description tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.
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spelling pubmed-47423292016-02-10 Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases Fu, Yu Lee, Inhan Lee, Yong Sun Bao, Xiaoyong Genomics Inform Review Article tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs. Korea Genome Organization 2015-12 2015-12-31 /pmc/articles/PMC4742329/ /pubmed/26865839 http://dx.doi.org/10.5808/GI.2015.13.4.94 Text en Copyright © 2015 by the Korea Genome Organization http://creativecommons.org/licenses/by-nc/4.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Review Article
Fu, Yu
Lee, Inhan
Lee, Yong Sun
Bao, Xiaoyong
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_full Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_fullStr Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_full_unstemmed Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_short Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
title_sort small non-coding transfer rna-derived rna fragments (trfs): their biogenesis, function and implication in human diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742329/
https://www.ncbi.nlm.nih.gov/pubmed/26865839
http://dx.doi.org/10.5808/GI.2015.13.4.94
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