Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as an important COPD susceptibility gene, with IRP2 protein increased in the lungs of individuals with COPD. Here...

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Detalles Bibliográficos
Autores principales: Cloonan, Suzanne M., Glass, Kimberly, Laucho-Contreras, Maria E., Bhashyam, Abhiram R., Cervo, Morgan, Pabón, Maria A., Konrad, Csaba, Polverino, Francesca, Siempos, Ilias I., Perez, Elizabeth, Mizumura, Kenji, Ghosh, Manik C., Parameswaran, Harikrishnan, Williams, Niamh C., Rooney, Kristen T., Chen, Zhi-Hua, Goldklang, Monica P., Yuan, Guo-Cheng, Moore, Stephen C., Demeo, Dawn L., Rouault, Tracey A., D’Armiento, Jeanine M., Schon, Eric A., Manfredi, Giovanni, Quackenbush, John, Mahmood, Ashfaq, Silverman, Edwin K., Owen, Caroline A., Choi, Augustine M.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742374/
https://www.ncbi.nlm.nih.gov/pubmed/26752519
http://dx.doi.org/10.1038/nm.4021

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