Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer

Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been r...

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Detalles Bibliográficos
Autores principales: Zhang, Haiyang, Duan, Jingjing, Qu, Yanjun, Deng, Ting, Liu, Rui, Zhang, Le, Bai, Ming, Li, Jialu, Ning, Tao, Ge, Shaohua, Wang, Xia, Wang, Zhenzhen, Fan, Qian, Li, Hongli, Ying, Guoguang, Huang, Dingzhi, Ba, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742383/
https://www.ncbi.nlm.nih.gov/pubmed/26758252
http://dx.doi.org/10.1007/s13238-015-0234-5
Descripción
Sumario:Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3′UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.

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