The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells

Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs....

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Detalles Bibliográficos
Autores principales: Zhao, Zhiju, Li, Shu, Song, Erwei, Liu, Suling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742390/
https://www.ncbi.nlm.nih.gov/pubmed/26349457
http://dx.doi.org/10.1007/s13238-015-0199-4
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author Zhao, Zhiju
Li, Shu
Song, Erwei
Liu, Suling
author_facet Zhao, Zhiju
Li, Shu
Song, Erwei
Liu, Suling
author_sort Zhao, Zhiju
collection PubMed
description Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs. Combining conventional treatments with therapeutic drugs targeting to CSCs will eradicate cancer cells more efficiently. Studying the molecular mechanisms of CSCs regulation is essential for developing new therapeutic strategies. Growing evidences showed CSCs are regulated by non-coding RNA (ncRNA) including microRNAs and long non-coding RNAs (lncRNAs), and histone-modifiers, such as let-7, miR-93, miR-100, HOTAIR, Bmi-1 and EZH2. Herein we review the roles of microRNAs, lncRNAs and histone-modifiers especially Polycomb family proteins in regulating breast cancer stem cells (BCSCs).
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spelling pubmed-47423902016-02-16 The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells Zhao, Zhiju Li, Shu Song, Erwei Liu, Suling Protein Cell Review Cancer stem cells (CSCs), a subpopulation of cancer cells with ability of initiating tumorigenesis, exist in many kinds of tumors including breast cancer. Cancer stem cells contribute to treatment resistance and relapse. Conventional treatments only kill differentiated cancer cells, but spare CSCs. Combining conventional treatments with therapeutic drugs targeting to CSCs will eradicate cancer cells more efficiently. Studying the molecular mechanisms of CSCs regulation is essential for developing new therapeutic strategies. Growing evidences showed CSCs are regulated by non-coding RNA (ncRNA) including microRNAs and long non-coding RNAs (lncRNAs), and histone-modifiers, such as let-7, miR-93, miR-100, HOTAIR, Bmi-1 and EZH2. Herein we review the roles of microRNAs, lncRNAs and histone-modifiers especially Polycomb family proteins in regulating breast cancer stem cells (BCSCs). Higher Education Press 2015-09-08 2016-02 /pmc/articles/PMC4742390/ /pubmed/26349457 http://dx.doi.org/10.1007/s13238-015-0199-4 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Zhao, Zhiju
Li, Shu
Song, Erwei
Liu, Suling
The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title_full The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title_fullStr The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title_full_unstemmed The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title_short The roles of ncRNAs and histone-modifiers in regulating breast cancer stem cells
title_sort roles of ncrnas and histone-modifiers in regulating breast cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742390/
https://www.ncbi.nlm.nih.gov/pubmed/26349457
http://dx.doi.org/10.1007/s13238-015-0199-4
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