Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Neutrophil extracellular traps (NETs) are implicated in autoimmunity but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes, inducers of NETosis, require mitochondrial ROS for maximal NET stimulation. During this process, mitochondria be...

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Detalles Bibliográficos
Autores principales: Lood, Christian, Blanco, Luz P., Purmalek, Monica M., Carmona-Rivera, Carmelo, De Ravin, Suk S., Smith, Carolyne K., Malech, Harry L., Ledbetter, Jeffrey A., Elkon, Keith B., Kaplan, Mariana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742415/
https://www.ncbi.nlm.nih.gov/pubmed/26779811
http://dx.doi.org/10.1038/nm.4027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742415/
https://www.ncbi.nlm.nih.gov/pubmed/26779811
http://dx.doi.org/10.1038/nm.4027

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