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Signaling Pathways in Osteoclast Differentiation

Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB li...

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Detalles Bibliográficos
Autores principales: Kim, Jung Ha, Kim, Nacksung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742606/
https://www.ncbi.nlm.nih.gov/pubmed/26865996
http://dx.doi.org/10.4068/cmj.2016.52.1.12
Descripción
Sumario:Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.