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The NADase-Negative Variant of the Streptococcus pyogenes Toxin NAD(+) Glycohydrolase Induces JNK1-Mediated Programmed Cellular Necrosis

Virulence factors are often multifunctional and contribute to pathogenesis through synergistic mechanisms. For the human pathogen Streptococcus pyogenes, two factors that act synergistically are the S. pyogenes NAD(+) glycohydrolase (SPN) and streptolysin O (SLO). Through distinct mechanisms, SLO fo...

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Detalles Bibliográficos
Autores principales:	Chandrasekaran, Sukantha, Caparon, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742715/ https://www.ncbi.nlm.nih.gov/pubmed/26838722 http://dx.doi.org/10.1128/mBio.02215-15

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