Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis

Glioblastomas have been proposed to be maintained by highly tumorigenic glioblastoma stem cells (GSCs) that are resistant to current therapy. Therefore, targeting GSCs is critical for developing effective therapies for glioblastoma. In this study, we identify the regulatory cascade of the nuclear re...

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Detalles Bibliográficos
Autores principales: Cui, Qi, Yang, Su, Ye, Peng, Tian, E., Sun, Guoqiang, Zhou, Jiehua, Sun, Guihua, Liu, Xiaoxuan, Chen, Chao, Murai, Kiyohito, Zhao, Chunnian, Azizian, Krist T., Yang, Lu, Warden, Charles, Wu, Xiwei, D'Apuzzo, Massimo, Brown, Christine, Badie, Behnam, Peng, Ling, Riggs, Arthur D., Rossi, John J., Shi, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742843/
https://www.ncbi.nlm.nih.gov/pubmed/26838672
http://dx.doi.org/10.1038/ncomms10637

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