BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma

Glioblastoma is an aggressive, invasive tumor of the central nervous system (CNS). There is a widely acknowledged need for anti-invasive therapeutics to limit glioblastoma invasion. BKM-120 is a CNS-penetrant pan-class I phosphatidyl-inositol-3 kinase (PI3K) inhibitor in clinical trials for solid tu...

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Detalles Bibliográficos
Autores principales: Speranza, Maria-Carmela, Nowicki, Michal O., Behera, Prajna, Cho, Choi-Fong, Chiocca, E. Antonio, Lawler, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742861/
https://www.ncbi.nlm.nih.gov/pubmed/26846842
http://dx.doi.org/10.1038/srep20189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742861/
https://www.ncbi.nlm.nih.gov/pubmed/26846842
http://dx.doi.org/10.1038/srep20189

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