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Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study

Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-...

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Autores principales: Lin, Lian-Yu, Wu, Cho-Kai, Juang, Jyh-Ming Jimmy, Wang, Yi-Chih, Su, Mao-Yuan Marine, Lai, Ling-Ping, Hwang, Juey-Jen, Chiang, Fu-Tien, Tseng, Wen-Yih Issac, Lin, Jiunn-Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742892/
https://www.ncbi.nlm.nih.gov/pubmed/26846306
http://dx.doi.org/10.1038/srep20711
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author Lin, Lian-Yu
Wu, Cho-Kai
Juang, Jyh-Ming Jimmy
Wang, Yi-Chih
Su, Mao-Yuan Marine
Lai, Ling-Ping
Hwang, Juey-Jen
Chiang, Fu-Tien
Tseng, Wen-Yih Issac
Lin, Jiunn-Lee
author_facet Lin, Lian-Yu
Wu, Cho-Kai
Juang, Jyh-Ming Jimmy
Wang, Yi-Chih
Su, Mao-Yuan Marine
Lai, Ling-Ping
Hwang, Juey-Jen
Chiang, Fu-Tien
Tseng, Wen-Yih Issac
Lin, Jiunn-Lee
author_sort Lin, Lian-Yu
collection PubMed
description Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysyn_max) and standard deviation (Dysyn_sd) of all Tmv. The results showed that among the covariates, only age (1.87, 95% CI: 0.61–3.13, p = 0.004) and ECV (3.77, 95% CI: 2.72–4.81, p < 0.001) were positively associated with Tmv. The results remained robust in certain subgroups. In conclusion, we demonstrated that LV myocardium regional variation in interstitial fibrosis is closely related to LV intra-ventricular dyssynchrony irrespective of the LV global function. These data might help explain the pathophysiology of LV dyssynchrony and it’s underlying mechanisms leading to poor prognosis.
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spelling pubmed-47428922016-02-09 Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study Lin, Lian-Yu Wu, Cho-Kai Juang, Jyh-Ming Jimmy Wang, Yi-Chih Su, Mao-Yuan Marine Lai, Ling-Ping Hwang, Juey-Jen Chiang, Fu-Tien Tseng, Wen-Yih Issac Lin, Jiunn-Lee Sci Rep Article Left ventricular (LV) dyssynchrony is associated with poor prognosis in patients with heart failure (HF). The mechanisms leading to LV dyssynchrony are not fully elucidated. This study evaluates whether myocardium regional variation in interstitial fibrosis is associated with LV dyssynchrony. Forty-two patients with systolic heart failure (SHF), 76 patients with heart failure with preserved ejection fraction (HFpEF) and 20 patients without HF received cardiovascular magnetic resonance imaging (MRI) study. LV was divided into 18 segments by short-axis view. In each segment, regional extracellular volume fraction (ECV) and the time taken to reach minimum regional volume (Tmv) were derived. Intra-LV dyssynchrony were represented by maximum difference (Dysyn_max) and standard deviation (Dysyn_sd) of all Tmv. The results showed that among the covariates, only age (1.87, 95% CI: 0.61–3.13, p = 0.004) and ECV (3.77, 95% CI: 2.72–4.81, p < 0.001) were positively associated with Tmv. The results remained robust in certain subgroups. In conclusion, we demonstrated that LV myocardium regional variation in interstitial fibrosis is closely related to LV intra-ventricular dyssynchrony irrespective of the LV global function. These data might help explain the pathophysiology of LV dyssynchrony and it’s underlying mechanisms leading to poor prognosis. Nature Publishing Group 2016-02-05 /pmc/articles/PMC4742892/ /pubmed/26846306 http://dx.doi.org/10.1038/srep20711 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lin, Lian-Yu
Wu, Cho-Kai
Juang, Jyh-Ming Jimmy
Wang, Yi-Chih
Su, Mao-Yuan Marine
Lai, Ling-Ping
Hwang, Juey-Jen
Chiang, Fu-Tien
Tseng, Wen-Yih Issac
Lin, Jiunn-Lee
Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title_full Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title_fullStr Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title_full_unstemmed Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title_short Myocardial Regional Interstitial Fibrosis is Associated With Left Intra-Ventricular Dyssynchrony in Patients With Heart Failure: A Cardiovascular Magnetic Resonance Study
title_sort myocardial regional interstitial fibrosis is associated with left intra-ventricular dyssynchrony in patients with heart failure: a cardiovascular magnetic resonance study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742892/
https://www.ncbi.nlm.nih.gov/pubmed/26846306
http://dx.doi.org/10.1038/srep20711
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