Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis

Age-related decreases in autophagy contribute to the progression of age-related macular degeneration (AMD). We have now studied the interaction between autophagy impaired in retinal pigment epithelium (RPE) and the responses of macrophages. We find that dying RPE cells can activate the macrophage in...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Copland, David A., Theodoropoulou, Sofia, Chiu, Hsi An Amy, Barba, Miriam Durazo, Mak, Ka Wang, Mack, Matthias, Nicholson, Lindsay B., Dick, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742917/
https://www.ncbi.nlm.nih.gov/pubmed/26847702
http://dx.doi.org/10.1038/srep20639

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