Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of thi...

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Detalles Bibliográficos
Autores principales: Dubeykovskaya, Zina, Si, Yiling, Chen, Xiaowei, Worthley, Daniel L., Renz, Bernhard W., Urbanska, Aleksandra M., Hayakawa, Yoku, Xu, Ting, Westphalen, C. Benedikt, Dubeykovskiy, Alexander, Chen, Duan, Friedman, Richard A., Asfaha, Samuel, Nagar, Karan, Tailor, Yagnesh, Muthupalani, Sureshkumar, Fox, James G., Kitajewski, Jan, Wang, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742920/
https://www.ncbi.nlm.nih.gov/pubmed/26841680
http://dx.doi.org/10.1038/ncomms10517

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