Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions

DNA-binding proteins search for specific targets via facilitated diffusion along a crowded genome. However, little is known about how crowded DNA modulates facilitated diffusion and target recognition. Here we use DNA curtains and single-molecule fluorescence imaging to investigate how Msh2–Msh3, a...

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Detalles Bibliográficos
Autores principales: Brown, Maxwell W., Kim, Yoori, Williams, Gregory M., Huck, John D., Surtees, Jennifer A., Finkelstein, Ilya J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742970/
https://www.ncbi.nlm.nih.gov/pubmed/26837705
http://dx.doi.org/10.1038/ncomms10607

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