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Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions
DNA-binding proteins search for specific targets via facilitated diffusion along a crowded genome. However, little is known about how crowded DNA modulates facilitated diffusion and target recognition. Here we use DNA curtains and single-molecule fluorescence imaging to investigate how Msh2–Msh3, a...
Autores principales: | Brown, Maxwell W., Kim, Yoori, Williams, Gregory M., Huck, John D., Surtees, Jennifer A., Finkelstein, Ilya J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742970/ https://www.ncbi.nlm.nih.gov/pubmed/26837705 http://dx.doi.org/10.1038/ncomms10607 |
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