Cargando…
Activating frataxin expression by repeat-targeted nucleic acids
Friedreich's ataxia is an incurable genetic disorder caused by a mutant expansion of the trinucleotide GAA within an intronic FXN RNA. This expansion leads to reduced expression of frataxin (FXN) protein and evidence suggests that transcriptional repression is caused by an R-loop that forms bet...
Autores principales: | Li, Liande, Matsui, Masayuki, Corey, David R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742999/ https://www.ncbi.nlm.nih.gov/pubmed/26842135 http://dx.doi.org/10.1038/ncomms10606 |
Ejemplares similares
-
Reduced Expression of Argonaute 1, Argonaute 2, and TRBP Changes Levels and Intracellular Distribution of RNAi Factors
por: Matsui, Masayuki, et al.
Publicado: (2015) -
Difficulties translating antisense-mediated activation of Frataxin expression from cell culture to mice
por: Kilikevicius, Audrius, et al.
Publicado: (2022) -
Targeting 3′ and 5′ untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression
por: Li, Yanjie, et al.
Publicado: (2021) -
The Replication of Frataxin Gene Is Assured by Activation of Dormant Origins in the Presence of a GAA-Repeat Expansion
por: Stevanoni, Martina, et al.
Publicado: (2016) -
Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich’s ataxia
por: Hackett, Peter T., et al.
Publicado: (2022)