The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling, leading to activation of NMD. Here we demonstrate the mechanism by which DHX34 fu...

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Detalles Bibliográficos
Autores principales: Melero, Roberto, Hug, Nele, López-Perrote, Andrés, Yamashita, Akio, Cáceres, Javier F., Llorca, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743010/
https://www.ncbi.nlm.nih.gov/pubmed/26841701
http://dx.doi.org/10.1038/ncomms10585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743010/
https://www.ncbi.nlm.nih.gov/pubmed/26841701
http://dx.doi.org/10.1038/ncomms10585

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