MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

The methyl-CpG-binding protein 2 (MeCP2) gene, MECP2, is an X-linked gene encoding the MeCP2 protein, and mutations of MECP2 cause Rett syndrome (RTT). However, the molecular mechanism of MECP2-mutation-caused RTT is less known. Here we find that MeCP2 could be SUMO-modified by the E3 ligase PIAS1 a...

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Detalles Bibliográficos
Autores principales: Tai, Derek J. C., Liu, Yen C., Hsu, Wei L., Ma, Yun L., Cheng, Sin J., Liu, Shau Y., Lee, Eminy H. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743023/
https://www.ncbi.nlm.nih.gov/pubmed/26842955
http://dx.doi.org/10.1038/ncomms10552

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