Cargando…
Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study
BACKGROUND: To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (PCa) on repeat biopsy. METHODS: Patients clinical charts from three European Ac...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743098/ https://www.ncbi.nlm.nih.gov/pubmed/26846521 http://dx.doi.org/10.1186/s12885-016-2085-8 |
_version_ | 1782414296491229184 |
---|---|
author | Cicione, Antonio De Nunzio, Cosimo Tubaro, Andrea Cantiello, Francesco Manno, Stefano Oliveira, Carlos Lima, Estevao Damiano, Rocco |
author_facet | Cicione, Antonio De Nunzio, Cosimo Tubaro, Andrea Cantiello, Francesco Manno, Stefano Oliveira, Carlos Lima, Estevao Damiano, Rocco |
author_sort | Cicione, Antonio |
collection | PubMed |
description | BACKGROUND: To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (PCa) on repeat biopsy. METHODS: Patients clinical charts from three European Academic Hospital were reviewed in order to identify patients with initial diagnosis of HGPIN undergone to repeat biopsy. Inclusion and exclusion criteria were adopted to minimize patient heterogeneity. MetS was defined according to Word Heart Organization criteria while initial wHGPIN when ≥4 cores biopsy were involved. A multivariate logistic model was computed to assess the association between PCa and clinical-pathological variables. RESULTS: Overall 283 patients were scheduled. Median age was 67 years (IQR 62–72). MetS was diagnosed in 116/283 (41 %) patients and PCa was detected in 84/283 (29.7 %) patients. In particular, PCa was more frequently diagnosed in patients affected of wHGPIN and MetS (45/86, 52.3 %) than in patients with wHGPIN and normal metabolic profile (28/95, 29.5 %), p = 0.002. The multivariate logistic model confirmed that wHGPIN and MetS are independent risk factors for following PCa diagnosis, respectively OR 2.4 (95 % CI 1.01–5.71, p = 0.04), OR 2.79 (95 % CI 1.49–5.22, p = 0.01) while total PSA and DRE findings are not able to predict PCa at repeat biopsy, OR 1.05 (95 % CI 0.98–1.03 p = 0.69) and OR 1.01 (95 % CI 0.55–1.84, p = 0.96) respectively. CONCLUSIONS: wHGPIN is positively associated to PCa; assessing metabolic profile and repeat prostate biopsy is advisable in patients with initial diagnosis of wHGPIN. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2085-8) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4743098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47430982016-02-06 Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study Cicione, Antonio De Nunzio, Cosimo Tubaro, Andrea Cantiello, Francesco Manno, Stefano Oliveira, Carlos Lima, Estevao Damiano, Rocco BMC Cancer Research Article BACKGROUND: To test in multicenter setting if patients affected of metabolic syndrome (MetS) and initial widespread high grade prostatic intraepithelial neoplasia (wHGPIN) diagnosis are at higher risk of prostate cancer (PCa) on repeat biopsy. METHODS: Patients clinical charts from three European Academic Hospital were reviewed in order to identify patients with initial diagnosis of HGPIN undergone to repeat biopsy. Inclusion and exclusion criteria were adopted to minimize patient heterogeneity. MetS was defined according to Word Heart Organization criteria while initial wHGPIN when ≥4 cores biopsy were involved. A multivariate logistic model was computed to assess the association between PCa and clinical-pathological variables. RESULTS: Overall 283 patients were scheduled. Median age was 67 years (IQR 62–72). MetS was diagnosed in 116/283 (41 %) patients and PCa was detected in 84/283 (29.7 %) patients. In particular, PCa was more frequently diagnosed in patients affected of wHGPIN and MetS (45/86, 52.3 %) than in patients with wHGPIN and normal metabolic profile (28/95, 29.5 %), p = 0.002. The multivariate logistic model confirmed that wHGPIN and MetS are independent risk factors for following PCa diagnosis, respectively OR 2.4 (95 % CI 1.01–5.71, p = 0.04), OR 2.79 (95 % CI 1.49–5.22, p = 0.01) while total PSA and DRE findings are not able to predict PCa at repeat biopsy, OR 1.05 (95 % CI 0.98–1.03 p = 0.69) and OR 1.01 (95 % CI 0.55–1.84, p = 0.96) respectively. CONCLUSIONS: wHGPIN is positively associated to PCa; assessing metabolic profile and repeat prostate biopsy is advisable in patients with initial diagnosis of wHGPIN. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-016-2085-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-04 /pmc/articles/PMC4743098/ /pubmed/26846521 http://dx.doi.org/10.1186/s12885-016-2085-8 Text en © Cicione et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Cicione, Antonio De Nunzio, Cosimo Tubaro, Andrea Cantiello, Francesco Manno, Stefano Oliveira, Carlos Lima, Estevao Damiano, Rocco Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title | Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title_full | Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title_fullStr | Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title_full_unstemmed | Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title_short | Metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
title_sort | metabolic syndrome diagnosis and widespread high grade prostatic intraepithelial neoplasia significantly increase prostate cancer risk: results from a multicenter biopsy study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743098/ https://www.ncbi.nlm.nih.gov/pubmed/26846521 http://dx.doi.org/10.1186/s12885-016-2085-8 |
work_keys_str_mv | AT cicioneantonio metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT denunziocosimo metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT tubaroandrea metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT cantiellofrancesco metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT mannostefano metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT oliveiracarlos metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT limaestevao metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy AT damianorocco metabolicsyndromediagnosisandwidespreadhighgradeprostaticintraepithelialneoplasiasignificantlyincreaseprostatecancerriskresultsfromamulticenterbiopsystudy |