Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

BACKGROUND: Previous studies have investigated the sustained aberrantly activated Interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is crucial for pancreatic cancer growth and metastasis. Suppressor of cytokine signaling 3 (SOCS3), as a key negative fe...

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Detalles Bibliográficos
Autores principales: Huang, Li, Hu, Bin, Ni, Jianbo, Wu, Jianghong, Jiang, Weiliang, Chen, Congying, Yang, Lijuan, Zeng, Yue, Wan, Rong, Hu, Guoyong, Wang, Xingpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743194/
https://www.ncbi.nlm.nih.gov/pubmed/26847351
http://dx.doi.org/10.1186/s13046-016-0301-7

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