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Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women
CONTEXT: Accurate assessment of thyroid function during pregnancy is critical, for initiation of thyroid hormone therapy, as well as for adjustment of thyroid hormone dose in hypothyroid cases. AIMS: We evaluated pregnant women who had no past history of thyroid disorders and studied their thyroid f...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743369/ https://www.ncbi.nlm.nih.gov/pubmed/26904477 http://dx.doi.org/10.4103/2230-8210.172239 |
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author | Sekhri, Tarun Juhi, Juhi Agarwal Wilfred, Reena Kanwar, Ratnesh S. Sethi, Jyoti Bhadra, Kuntal Nair, Sirimavo Singh, Satveer |
author_facet | Sekhri, Tarun Juhi, Juhi Agarwal Wilfred, Reena Kanwar, Ratnesh S. Sethi, Jyoti Bhadra, Kuntal Nair, Sirimavo Singh, Satveer |
author_sort | Sekhri, Tarun |
collection | PubMed |
description | CONTEXT: Accurate assessment of thyroid function during pregnancy is critical, for initiation of thyroid hormone therapy, as well as for adjustment of thyroid hormone dose in hypothyroid cases. AIMS: We evaluated pregnant women who had no past history of thyroid disorders and studied their thyroid function in each trimester. SETTINGS AND DESIGN: 86 normal pregnant women in the first trimester of pregnancy were selected for setting reference intervals. All were healthy, euthyroid and negative for thyroid peroxidase antibody (TPOAb). These women were serially followed throughout pregnancy. 124 normal nonpregnant subjects were selected for comparison. Material and methods: Thyrotropin (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and anti-TPO were measured using Roche Elecsys 1010 analyzer. Urinary iodine content was determined by simple microplate method. The 2.5th and 97.5th percentiles were calculated as the reference intervals for thyroid hormone levels during each trimester. STATISTICAL ANALYSIS: SPSS (version 14.0, SPSS Inc., Chicago, IL, USA) was used for data processing and analysis. RESULTS: The reference intervals for the first, second and third trimesters for the following parameters: TSH 0.09-6.65, 0.51-6.66, 0.91-4.86 µIU/mL, FT4 9.81-18.53, 8.52-19.43, 7.39-18.28 pM/L and FT3 3.1-6.35, 2.39-5.12, 2.57-5.68 pM/L respectively. Thyroid hormone concentrations significantly differed during pregnancy at different stages of gestation. The pregnant women in the study had median urinary iodine concentration of 150-200 µg/l during each trimester. CONCLUSIONS: The trimester-specific reference intervals for thyroid tests during pregnancy have been established for pregnant Indian women serially followed during pregnancy using 2.5th and 97.5th percentiles. |
format | Online Article Text |
id | pubmed-4743369 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47433692016-02-22 Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women Sekhri, Tarun Juhi, Juhi Agarwal Wilfred, Reena Kanwar, Ratnesh S. Sethi, Jyoti Bhadra, Kuntal Nair, Sirimavo Singh, Satveer Indian J Endocrinol Metab Original Article CONTEXT: Accurate assessment of thyroid function during pregnancy is critical, for initiation of thyroid hormone therapy, as well as for adjustment of thyroid hormone dose in hypothyroid cases. AIMS: We evaluated pregnant women who had no past history of thyroid disorders and studied their thyroid function in each trimester. SETTINGS AND DESIGN: 86 normal pregnant women in the first trimester of pregnancy were selected for setting reference intervals. All were healthy, euthyroid and negative for thyroid peroxidase antibody (TPOAb). These women were serially followed throughout pregnancy. 124 normal nonpregnant subjects were selected for comparison. Material and methods: Thyrotropin (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and anti-TPO were measured using Roche Elecsys 1010 analyzer. Urinary iodine content was determined by simple microplate method. The 2.5th and 97.5th percentiles were calculated as the reference intervals for thyroid hormone levels during each trimester. STATISTICAL ANALYSIS: SPSS (version 14.0, SPSS Inc., Chicago, IL, USA) was used for data processing and analysis. RESULTS: The reference intervals for the first, second and third trimesters for the following parameters: TSH 0.09-6.65, 0.51-6.66, 0.91-4.86 µIU/mL, FT4 9.81-18.53, 8.52-19.43, 7.39-18.28 pM/L and FT3 3.1-6.35, 2.39-5.12, 2.57-5.68 pM/L respectively. Thyroid hormone concentrations significantly differed during pregnancy at different stages of gestation. The pregnant women in the study had median urinary iodine concentration of 150-200 µg/l during each trimester. CONCLUSIONS: The trimester-specific reference intervals for thyroid tests during pregnancy have been established for pregnant Indian women serially followed during pregnancy using 2.5th and 97.5th percentiles. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4743369/ /pubmed/26904477 http://dx.doi.org/10.4103/2230-8210.172239 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sekhri, Tarun Juhi, Juhi Agarwal Wilfred, Reena Kanwar, Ratnesh S. Sethi, Jyoti Bhadra, Kuntal Nair, Sirimavo Singh, Satveer Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title | Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title_full | Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title_fullStr | Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title_full_unstemmed | Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title_short | Trimester specific reference intervals for thyroid function tests in normal Indian pregnant women |
title_sort | trimester specific reference intervals for thyroid function tests in normal indian pregnant women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743369/ https://www.ncbi.nlm.nih.gov/pubmed/26904477 http://dx.doi.org/10.4103/2230-8210.172239 |
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