Diabetes insipidus: The other diabetes

Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalra, Sanjay, Zargar, Abdul Hamid, Jain, Sunil M., Sethi, Bipin, Chowdhury, Subhankar, Singh, Awadhesh Kumar, Thomas, Nihal, Unnikrishnan, A. G., Thakkar, Piya Ballani, Malve, Harshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743391/
https://www.ncbi.nlm.nih.gov/pubmed/26904464
http://dx.doi.org/10.4103/2230-8210.172273
_version_ 1782414358251307008
author Kalra, Sanjay
Zargar, Abdul Hamid
Jain, Sunil M.
Sethi, Bipin
Chowdhury, Subhankar
Singh, Awadhesh Kumar
Thomas, Nihal
Unnikrishnan, A. G.
Thakkar, Piya Ballani
Malve, Harshad
author_facet Kalra, Sanjay
Zargar, Abdul Hamid
Jain, Sunil M.
Sethi, Bipin
Chowdhury, Subhankar
Singh, Awadhesh Kumar
Thomas, Nihal
Unnikrishnan, A. G.
Thakkar, Piya Ballani
Malve, Harshad
author_sort Kalra, Sanjay
collection PubMed
description Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin.
format Online
Article
Text
id pubmed-4743391
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-47433912016-02-22 Diabetes insipidus: The other diabetes Kalra, Sanjay Zargar, Abdul Hamid Jain, Sunil M. Sethi, Bipin Chowdhury, Subhankar Singh, Awadhesh Kumar Thomas, Nihal Unnikrishnan, A. G. Thakkar, Piya Ballani Malve, Harshad Indian J Endocrinol Metab Review Article Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4743391/ /pubmed/26904464 http://dx.doi.org/10.4103/2230-8210.172273 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Kalra, Sanjay
Zargar, Abdul Hamid
Jain, Sunil M.
Sethi, Bipin
Chowdhury, Subhankar
Singh, Awadhesh Kumar
Thomas, Nihal
Unnikrishnan, A. G.
Thakkar, Piya Ballani
Malve, Harshad
Diabetes insipidus: The other diabetes
title Diabetes insipidus: The other diabetes
title_full Diabetes insipidus: The other diabetes
title_fullStr Diabetes insipidus: The other diabetes
title_full_unstemmed Diabetes insipidus: The other diabetes
title_short Diabetes insipidus: The other diabetes
title_sort diabetes insipidus: the other diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743391/
https://www.ncbi.nlm.nih.gov/pubmed/26904464
http://dx.doi.org/10.4103/2230-8210.172273
work_keys_str_mv AT kalrasanjay diabetesinsipidustheotherdiabetes
AT zargarabdulhamid diabetesinsipidustheotherdiabetes
AT jainsunilm diabetesinsipidustheotherdiabetes
AT sethibipin diabetesinsipidustheotherdiabetes
AT chowdhurysubhankar diabetesinsipidustheotherdiabetes
AT singhawadheshkumar diabetesinsipidustheotherdiabetes
AT thomasnihal diabetesinsipidustheotherdiabetes
AT unnikrishnanag diabetesinsipidustheotherdiabetes
AT thakkarpiyaballani diabetesinsipidustheotherdiabetes
AT malveharshad diabetesinsipidustheotherdiabetes