Diabetes insipidus: The other diabetes
Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743391/ https://www.ncbi.nlm.nih.gov/pubmed/26904464 http://dx.doi.org/10.4103/2230-8210.172273 |
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author | Kalra, Sanjay Zargar, Abdul Hamid Jain, Sunil M. Sethi, Bipin Chowdhury, Subhankar Singh, Awadhesh Kumar Thomas, Nihal Unnikrishnan, A. G. Thakkar, Piya Ballani Malve, Harshad |
author_facet | Kalra, Sanjay Zargar, Abdul Hamid Jain, Sunil M. Sethi, Bipin Chowdhury, Subhankar Singh, Awadhesh Kumar Thomas, Nihal Unnikrishnan, A. G. Thakkar, Piya Ballani Malve, Harshad |
author_sort | Kalra, Sanjay |
collection | PubMed |
description | Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin. |
format | Online Article Text |
id | pubmed-4743391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47433912016-02-22 Diabetes insipidus: The other diabetes Kalra, Sanjay Zargar, Abdul Hamid Jain, Sunil M. Sethi, Bipin Chowdhury, Subhankar Singh, Awadhesh Kumar Thomas, Nihal Unnikrishnan, A. G. Thakkar, Piya Ballani Malve, Harshad Indian J Endocrinol Metab Review Article Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of persons with the condition; disruption is due to increased thirst and passing of large volumes of urine, even at night. A systematic search of literature for DI was carried out using the PubMed database for the purpose of this review. Central DI due to impaired secretion of arginine vasopressin (AVP) could result from traumatic brain injury, surgery, or tumors whereas nephrogenic DI due to failure of the kidney to respond to AVP is usually inherited. The earliest treatment was posterior pituitary extracts containing vasopressin and oxytocin. The synthetic analog of vasopressin, desmopressin has several benefits over vasopressin. Desmopressin was initially available as intranasal preparation, but now the oral tablet and melt formulations have gained significance, with benefits such as ease of administration and stability at room temperature. Other molecules used for treatment include chlorpropamide, carbamazepine, thiazide diuretics, indapamide, clofibrate, indomethacin, and amiloride. However, desmopressin remains the most widely used drug for the treatment of DI. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4743391/ /pubmed/26904464 http://dx.doi.org/10.4103/2230-8210.172273 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Kalra, Sanjay Zargar, Abdul Hamid Jain, Sunil M. Sethi, Bipin Chowdhury, Subhankar Singh, Awadhesh Kumar Thomas, Nihal Unnikrishnan, A. G. Thakkar, Piya Ballani Malve, Harshad Diabetes insipidus: The other diabetes |
title | Diabetes insipidus: The other diabetes |
title_full | Diabetes insipidus: The other diabetes |
title_fullStr | Diabetes insipidus: The other diabetes |
title_full_unstemmed | Diabetes insipidus: The other diabetes |
title_short | Diabetes insipidus: The other diabetes |
title_sort | diabetes insipidus: the other diabetes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743391/ https://www.ncbi.nlm.nih.gov/pubmed/26904464 http://dx.doi.org/10.4103/2230-8210.172273 |
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