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Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases
Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in parti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743591/ https://www.ncbi.nlm.nih.gov/pubmed/25193104 http://dx.doi.org/10.1586/14760584.2015.955478 |
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author | Terry, Frances E Moise, Leonard Martin, Rebecca F Torres, Melissa Pilotte, Nils Williams, Steven A De Groot, Anne S |
author_facet | Terry, Frances E Moise, Leonard Martin, Rebecca F Torres, Melissa Pilotte, Nils Williams, Steven A De Groot, Anne S |
author_sort | Terry, Frances E |
collection | PubMed |
description | Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere. |
format | Online Article Text |
id | pubmed-4743591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-47435912016-02-24 Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases Terry, Frances E Moise, Leonard Martin, Rebecca F Torres, Melissa Pilotte, Nils Williams, Steven A De Groot, Anne S Expert Rev Vaccines Review Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world’s poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines for EID and neglected tropical diseases all the more difficult. In this review, we describe the implementation of an immunoinformatics-driven approach to systematically search for key determinants of immunity in newly available genome sequence data and design vaccines. This approach holds promise for the development of 21st century vaccines, improving human health everywhere. Informa Healthcare 2014-09-05 /pmc/articles/PMC4743591/ /pubmed/25193104 http://dx.doi.org/10.1586/14760584.2015.955478 Text en Informa UK, Ltd. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Review Terry, Frances E Moise, Leonard Martin, Rebecca F Torres, Melissa Pilotte, Nils Williams, Steven A De Groot, Anne S Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title | Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title_full | Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title_fullStr | Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title_full_unstemmed | Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title_short | Time for T? Immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
title_sort | time for t? immunoinformatics addresses vaccine design for neglected tropical and emerging infectious diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743591/ https://www.ncbi.nlm.nih.gov/pubmed/25193104 http://dx.doi.org/10.1586/14760584.2015.955478 |
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