IsoMIF Finder: online detection of binding site molecular interaction field similarities

Summary: IsoMIF Finder is an online server for the identification of molecular interaction field (MIF) similarities. User defined binding site MIFs can be compared to datasets of pre-calculated MIFs or against a user-defined list of PDB entries. The interface can be used for the prediction of functi...

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Detalles Bibliográficos
Autores principales: Chartier, Matthieu, Adriansen, Etienne, Najmanovich, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743630/
https://www.ncbi.nlm.nih.gov/pubmed/26504139
http://dx.doi.org/10.1093/bioinformatics/btv616
Descripción
Sumario:Summary: IsoMIF Finder is an online server for the identification of molecular interaction field (MIF) similarities. User defined binding site MIFs can be compared to datasets of pre-calculated MIFs or against a user-defined list of PDB entries. The interface can be used for the prediction of function, identification of potential cross-reactivity or polypharmacological targets and drug repurposing. Detected similarities can be viewed in a browser or within a PyMOL session. Availability and Implementation: IsoMIF Finder uses JSMOL (no java plugin required), is cross-browser and freely available at bcb.med.usherbrooke.ca/imfi. Contact: Rafael.Najmanovich@Usherbrooke.ca Supplementary information: Supplementary data are available at Bioinformatics online.

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