The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6(−/−) shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand

The congenital malformation split hand/foot (SHFM) is characterized by missing central fingers and dysmorphology or fusion of the remaining ones. Type-1 SHFM is linked to deletions/rearrangements of the DLX5–DLX6 locus and point mutations in the DLX5 gene. The ectrodactyly phenotype is reproduced in...

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Detalles Bibliográficos
Autores principales: Conte, Daniele, Garaffo, Giulia, Lo Iacono, Nadia, Mantero, Stefano, Piccolo, Stefano, Cordenonsi, Michelangelo, Perez-Morga, David, Orecchia, Valeria, Poli, Valeria, Merlo, Giorgio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743692/
https://www.ncbi.nlm.nih.gov/pubmed/26685160
http://dx.doi.org/10.1093/hmg/ddv514

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