Cargando…

Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis

Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis in other skin areas. We sought to determine the cellular and molec...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruano, Juan, Suárez-Fariñas, Mayte, Shemer, Avner, Oliva, Margeaux, Guttman-Yassky, Emma, Krueger, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743842/
https://www.ncbi.nlm.nih.gov/pubmed/26849645
http://dx.doi.org/10.1371/journal.pone.0148450
_version_ 1782414401258651648
author Ruano, Juan
Suárez-Fariñas, Mayte
Shemer, Avner
Oliva, Margeaux
Guttman-Yassky, Emma
Krueger, James G.
author_facet Ruano, Juan
Suárez-Fariñas, Mayte
Shemer, Avner
Oliva, Margeaux
Guttman-Yassky, Emma
Krueger, James G.
author_sort Ruano, Juan
collection PubMed
description Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis in other skin areas. We sought to determine the cellular and molecular phenotype of scalp psoriasis by performing a comparative analysis of scalp and skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement and 10 control subjects without psoriasis. Our results suggest that even in the scalp, psoriasis is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis were found to be similar to those involved in skin psoriasis. However, the magnitude of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic genomic fingerprint were more prominent in skin lesions. Furthermore, the scalp transcriptome showed increased modulation of several gene-sets, particularly those induced by interferon-gamma, compared with that of skin psoriasis, which was mainly associated with activation of TNFα/L-17/IL-22-induced keratinocyte response genes. We also detected differences in expression of gene-sets involving negative regulation, epigenetic regulation, epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes.
format Online
Article
Text
id pubmed-4743842
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-47438422016-02-11 Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis Ruano, Juan Suárez-Fariñas, Mayte Shemer, Avner Oliva, Margeaux Guttman-Yassky, Emma Krueger, James G. PLoS One Research Article Scalp psoriasis shows a variable clinical spectrum and in many cases poses a great therapeutic challenge. However, it remains unknown whether the immune response of scalp psoriasis differs from understood pathomechanisms of psoriasis in other skin areas. We sought to determine the cellular and molecular phenotype of scalp psoriasis by performing a comparative analysis of scalp and skin using lesional and nonlesional samples from 20 Caucasian subjects with untreated moderate to severe psoriasis and significant scalp involvement and 10 control subjects without psoriasis. Our results suggest that even in the scalp, psoriasis is a disease of the inter-follicular skin. The immune mechanisms that mediate scalp psoriasis were found to be similar to those involved in skin psoriasis. However, the magnitude of dysregulation, number of differentially expressed genes, and enrichment of the psoriatic genomic fingerprint were more prominent in skin lesions. Furthermore, the scalp transcriptome showed increased modulation of several gene-sets, particularly those induced by interferon-gamma, compared with that of skin psoriasis, which was mainly associated with activation of TNFα/L-17/IL-22-induced keratinocyte response genes. We also detected differences in expression of gene-sets involving negative regulation, epigenetic regulation, epidermal differentiation, and dendritic cell or Th1/Th17/Th22-related T-cell processes. Public Library of Science 2016-02-05 /pmc/articles/PMC4743842/ /pubmed/26849645 http://dx.doi.org/10.1371/journal.pone.0148450 Text en © 2016 Ruano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ruano, Juan
Suárez-Fariñas, Mayte
Shemer, Avner
Oliva, Margeaux
Guttman-Yassky, Emma
Krueger, James G.
Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title_full Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title_fullStr Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title_full_unstemmed Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title_short Molecular and Cellular Profiling of Scalp Psoriasis Reveals Differences and Similarities Compared to Skin Psoriasis
title_sort molecular and cellular profiling of scalp psoriasis reveals differences and similarities compared to skin psoriasis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743842/
https://www.ncbi.nlm.nih.gov/pubmed/26849645
http://dx.doi.org/10.1371/journal.pone.0148450
work_keys_str_mv AT ruanojuan molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis
AT suarezfarinasmayte molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis
AT shemeravner molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis
AT olivamargeaux molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis
AT guttmanyasskyemma molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis
AT kruegerjamesg molecularandcellularprofilingofscalppsoriasisrevealsdifferencesandsimilaritiescomparedtoskinpsoriasis