The Replisome-Coupled E3 Ubiquitin Ligase Rtt101(Mms22) Counteracts Mrc1 Function to Tolerate Genotoxic Stress

Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of...

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Detalles Bibliográficos
Autores principales: Buser, Raymond, Kellner, Vanessa, Melnik, Andre, Wilson-Zbinden, Caroline, Schellhaas, René, Kastner, Lisa, Piwko, Wojciech, Dees, Martina, Picotti, Paola, Maric, Marija, Labib, Karim, Luke, Brian, Peter, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743919/
https://www.ncbi.nlm.nih.gov/pubmed/26849847
http://dx.doi.org/10.1371/journal.pgen.1005843

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