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Anti-Inflammatory Effects of β(2)-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1

Mitogen-activated protein kinase phosphatase 1 (MKP-1) expression is induced by inflammatory factors, and it is an endogenous suppressor of inflammatory response. MKP-1 expression is increased by PDE4 inhibitor rolipram suggesting that it is regulated by cAMP-enhancing compounds. Therefore, we inves...

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Detalles Bibliográficos
Autores principales: Keränen, Tiina, Hömmö, Tuija, Hämäläinen, Mari, Moilanen, Eeva, Korhonen, Riku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743993/
https://www.ncbi.nlm.nih.gov/pubmed/26849227
http://dx.doi.org/10.1371/journal.pone.0148144