Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis

BACKGROUND: Epstein-Barr virus (EBV) infection represents a major environmental risk factor for multiple sclerosis (MS), with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1)-specific CD4+ T cells that cross-recognize MS-associated myelin antigens in MS patients. HLA-DRB1*15...

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Detalles Bibliográficos
Autores principales: Tschochner, Monika, Leary, Shay, Cooper, Don, Strautins, Kaija, Chopra, Abha, Clark, Hayley, Choo, Linda, Dunn, David, James, Ian, Carroll, William M., Kermode, Allan G., Nolan, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744032/
https://www.ncbi.nlm.nih.gov/pubmed/26849221
http://dx.doi.org/10.1371/journal.pone.0147567

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