A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy

Whole exome sequencing can identify somatic mutations in malignant tumors and allow for personalized and novel treatment of common malignancies. Mutations in the BRAF gene are rare in renal cell carcinoma, and thus, BRAF inhibitors are not considered standard in the treatment of these cancers. Here,...

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Detalles Bibliográficos
Autores principales: Banerjee, Natasha, Sachdev, Esha, Figlin, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2016
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744077/
https://www.ncbi.nlm.nih.gov/pubmed/26918217
http://dx.doi.org/10.7759/cureus.449
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author Banerjee, Natasha
Sachdev, Esha
Figlin, Robert A
author_facet Banerjee, Natasha
Sachdev, Esha
Figlin, Robert A
author_sort Banerjee, Natasha
collection PubMed
description Whole exome sequencing can identify somatic mutations in malignant tumors and allow for personalized and novel treatment of common malignancies. Mutations in the BRAF gene are rare in renal cell carcinoma, and thus, BRAF inhibitors are not considered standard in the treatment of these cancers. Here, we report a case of a patient with a rare BRAF-mutated metastatic renal cell carcinoma who obtained a good clinical response to BRAF inhibition. This case underscores the value of precision medicine in an era of rapidly evolving therapeutics for malignancies.
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spelling pubmed-47440772016-02-25 A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy Banerjee, Natasha Sachdev, Esha Figlin, Robert A Cureus Oncology Whole exome sequencing can identify somatic mutations in malignant tumors and allow for personalized and novel treatment of common malignancies. Mutations in the BRAF gene are rare in renal cell carcinoma, and thus, BRAF inhibitors are not considered standard in the treatment of these cancers. Here, we report a case of a patient with a rare BRAF-mutated metastatic renal cell carcinoma who obtained a good clinical response to BRAF inhibition. This case underscores the value of precision medicine in an era of rapidly evolving therapeutics for malignancies. Cureus 2016-01-06 /pmc/articles/PMC4744077/ /pubmed/26918217 http://dx.doi.org/10.7759/cureus.449 Text en Copyright © 2016, Banerjee et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Banerjee, Natasha
Sachdev, Esha
Figlin, Robert A
A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title_full A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title_fullStr A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title_full_unstemmed A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title_short A Rare Finding of a BRAF Mutation in Renal Cell Carcinoma with Response to BRAF-Directed Targeted Therapy
title_sort rare finding of a braf mutation in renal cell carcinoma with response to braf-directed targeted therapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744077/
https://www.ncbi.nlm.nih.gov/pubmed/26918217
http://dx.doi.org/10.7759/cureus.449
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