Cargando…

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay

Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nomakuchi, Tomoki T., Rigo, Frank, Aznarez, Isabel, Krainer, Adrian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744113/ https://www.ncbi.nlm.nih.gov/pubmed/26655495 http://dx.doi.org/10.1038/nbt.3427

Ejemplares similares

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1
por: Aznarez, Isabel, et al.
Publicado: (2018)

Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy
por: Kim, Young Jin, et al.
Publicado: (2022)

Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides
por: Ward, Amanda J., et al.
Publicado: (2014)

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice
por: Sinha, Rahul, et al.
Publicado: (2018)

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides
por: Wang, Zhenxun, et al.
Publicado: (2012)

Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides
por: Scharner, Juergen, et al.
Publicado: (2020)

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
por: Khoo, Bernard, et al.
Publicado: (2007)

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model
por: Sheng, Lei, et al.
Publicado: (2020)

Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene
por: Kralovicova, Jana, et al.
Publicado: (2016)

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway
por: Liang, Xue-hai, et al.
Publicado: (2019)

Antisense Oligonucleotide Therapeutics for Cystic Fibrosis: Recent Developments and Perspectives
por: Kim, Young Jin, et al.
Publicado: (2023)

Attenuation of Nonsense-Mediated mRNA Decay Enhances In Vivo Nonsense Suppression
por: Keeling, Kim M., et al.
Publicado: (2013)

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors
por: Mailliot, Justine, et al.
Publicado: (2022)

Aberrant mRNA transcripts and nonsense-mediated decay
por: Trinkle-Mulcahy, Laura
Publicado: (2009)

Viral subversion of nonsense-mediated mRNA decay
por: Popp, Maximilian Wei-Lin, et al.
Publicado: (2020)

Cellular variability of nonsense-mediated mRNA decay
por: Sato, Hanae, et al.
Publicado: (2021)

Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein
por: Mocquet, Vincent, et al.
Publicado: (2014)

Nonsense-Mediated mRNA Decay as a Mediator of Tumorigenesis
por: Nagar, Preeti, et al.
Publicado: (2023)

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay
por: Nguyen, Andrew D., et al.
Publicado: (2018)

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides
por: Gill, Taylor, et al.
Publicado: (2021)

Targeting Translation Termination Machinery with Antisense Oligonucleotides for Diseases Caused by Nonsense Mutations
por: Huang, Lulu, et al.
Publicado: (2019)

Heritability in the Efficiency of Nonsense-Mediated mRNA Decay in Humans
por: Seoighe, Cathal, et al.
Publicado: (2010)

Intracellular Calcium Regulates Nonsense-Mediated mRNA Decay
por: Nickless, Andrew, et al.
Publicado: (2014)

The Dharma of Nonsense-Mediated mRNA Decay in Mammalian Cells
por: Popp, Maximilian Wei-Lin, et al.
Publicado: (2014)

The Substrates of Nonsense-Mediated mRNA Decay in Caenorhabditis elegans
por: Muir, Virginia S., et al.
Publicado: (2017)

The evolution and diversity of the nonsense-mediated mRNA decay pathway
por: Lloyd, James P. B.
Publicado: (2018)

Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
por: Ahmed, Md Robel, et al.
Publicado: (2023)

Mechanisms and Regulation of Nonsense-Mediated mRNA Decay and Nonsense-Associated Altered Splicing in Lymphocytes
por: Lambert, Jean-Marie, et al.
Publicado: (2020)

Exon-skipping antisense oligonucleotides for cystic fibrosis therapy
por: Kim, Young Jin, et al.
Publicado: (2022)

Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells
por: Nasif, Sofia, et al.
Publicado: (2023)

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon
por: Hua, Yimin, et al.
Publicado: (2007)

Antisense-based therapy for the treatment of spinal muscular atrophy
por: Rigo, Frank, et al.
Publicado: (2012)

Nonsense mRNA suppression via nonstop decay
por: Arribere, Joshua A, et al.
Publicado: (2018)

Suppression of prostate tumor cell survival by antisense oligonucleotide-mediated inhibition of AR-V7 mRNA synthesis
por: Luna Velez, Maria V., et al.
Publicado: (2019)

Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides
por: Ham, Kristin A., et al.
Publicado: (2021)

Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay
por: Obenoskey, Jesseeca, et al.
Publicado: (2014)

Nonsense-mediated mRNA decay: a ‘nonsense’ pathway makes sense in stem cell biology
por: Han, Xin, et al.
Publicado: (2018)

Functions of the Nonsense-Mediated mRNA Decay Pathway in Drosophila Development
por: Metzstein, Mark M, et al.
Publicado: (2006)

Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics
por: Popp, Maximilian W., et al.
Publicado: (2015)

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay
por: Balistreri, Giuseppe, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pn8pfda0svjg92ss2ic68jucju