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Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

Mutations in the catalytic subunit of phosphoinositide 3-kinase (PIK3CA) and other PI3K-AKT pathway components have been associated with cancer and a wide spectrum of brain and body overgrowth. In the brain, the phenotypic spectrum of PIK3CA-related segmental overgrowth includes bilateral dysplastic...

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Detalles Bibliográficos
Autores principales:	Roy, Achira, Skibo, Jonathan, Kalume, Franck, Ni, Jing, Rankin, Sherri, Lu, Yiling, Dobyns, William B, Mills, Gordon B, Zhao, Jean J, Baker, Suzanne J, Millen, Kathleen J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Human Biology and Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744197/ https://www.ncbi.nlm.nih.gov/pubmed/26633882 http://dx.doi.org/10.7554/eLife.12703

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