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Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

We investigate the in vivo patterns of stem cell divisions in the human hematopoietic system throughout life. In particular, we analyze the shape of telomere length distributions underlying stem cell behavior within individuals. Our mathematical model shows that these distributions contain a fingerp...

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Detalles Bibliográficos
Autores principales:	Werner, Benjamin, Beier, Fabian, Hummel, Sebastian, Balabanov, Stefan, Lassay, Lisa, Orlikowsky, Thorsten, Dingli, David, Brümmendorf, Tim H, Traulsen, Arne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744200/ https://www.ncbi.nlm.nih.gov/pubmed/26468615 http://dx.doi.org/10.7554/eLife.08687

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