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Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice

BACKGROUND: Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with s...

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Autores principales: Park, Jung-Cheol, Ma, Jinhua, Jeon, Won Kyung, Han, Jung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744392/
https://www.ncbi.nlm.nih.gov/pubmed/26852239
http://dx.doi.org/10.1186/s12906-016-1033-0
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author Park, Jung-Cheol
Ma, Jinhua
Jeon, Won Kyung
Han, Jung-Soo
author_facet Park, Jung-Cheol
Ma, Jinhua
Jeon, Won Kyung
Han, Jung-Soo
author_sort Park, Jung-Cheol
collection PubMed
description BACKGROUND: Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with scopolamine treatments. The present experiment was conducted to examine the effects of F. mume on cognitive impairments in 5XFAD transgenic mice with five familial Alzheimer’s disease (AD) mutations. METHODS: F. mume was administered daily to 5XFAD mice at 12 weeks of age and continued for 90 days. Cognitive function was evaluated using a spatial memory version of the Morris water maze task, the object/location novelty recognition test, and contextual fear conditioning at 24 weeks of age. To elucidate the possible mechanisms underlying the memory improving effects of F. mume in 5XFAD mice, we examined alterations in hippocampal cholinergic function. RESULTS: Vehicle-treated 5XFAD mice exhibited hippocampus-dependent memory impairments compared with non-transgenic littermates, which was reversed in F. mume-treated 5XFAD mice. In addition, reduced hippocampal choline acetyltransferase (ChAT) levels in 5XFAD mice were reversed by F. mume treatment, indicating that F. mume enhances the effects of cholinergic neuronal function. CONCLUSIONS: F. mume may have therapeutic effects on cognitive impairments in AD.
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spelling pubmed-47443922016-02-07 Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice Park, Jung-Cheol Ma, Jinhua Jeon, Won Kyung Han, Jung-Soo BMC Complement Altern Med Research Article BACKGROUND: Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with scopolamine treatments. The present experiment was conducted to examine the effects of F. mume on cognitive impairments in 5XFAD transgenic mice with five familial Alzheimer’s disease (AD) mutations. METHODS: F. mume was administered daily to 5XFAD mice at 12 weeks of age and continued for 90 days. Cognitive function was evaluated using a spatial memory version of the Morris water maze task, the object/location novelty recognition test, and contextual fear conditioning at 24 weeks of age. To elucidate the possible mechanisms underlying the memory improving effects of F. mume in 5XFAD mice, we examined alterations in hippocampal cholinergic function. RESULTS: Vehicle-treated 5XFAD mice exhibited hippocampus-dependent memory impairments compared with non-transgenic littermates, which was reversed in F. mume-treated 5XFAD mice. In addition, reduced hippocampal choline acetyltransferase (ChAT) levels in 5XFAD mice were reversed by F. mume treatment, indicating that F. mume enhances the effects of cholinergic neuronal function. CONCLUSIONS: F. mume may have therapeutic effects on cognitive impairments in AD. BioMed Central 2016-02-06 /pmc/articles/PMC4744392/ /pubmed/26852239 http://dx.doi.org/10.1186/s12906-016-1033-0 Text en © Park et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Park, Jung-Cheol
Ma, Jinhua
Jeon, Won Kyung
Han, Jung-Soo
Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title_full Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title_fullStr Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title_full_unstemmed Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title_short Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
title_sort fructus mume extracts alleviate cognitive impairments in 5xfad transgenic mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744392/
https://www.ncbi.nlm.nih.gov/pubmed/26852239
http://dx.doi.org/10.1186/s12906-016-1033-0
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