High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells

BACKGROUND: Pseudomonas fluorescens lectin (PFL) belongs to a recently discovered anti-HIV lectin family and induces anoikis-like cell death of MKN28 gastric cancer cells by causing α2 integrin internalization through recognition of high mannose glycans; however, the detailed anti-cancer mechanism i...

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Detalles Bibliográficos
Autores principales: Sato, Yuichiro, Kubo, Takanori, Morimoto, Kinjiro, Yanagihara, Kazuyoshi, Seyama, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744433/
https://www.ncbi.nlm.nih.gov/pubmed/26850110
http://dx.doi.org/10.1186/s12885-016-2099-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744433/
https://www.ncbi.nlm.nih.gov/pubmed/26850110
http://dx.doi.org/10.1186/s12885-016-2099-2

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