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At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei

AIMS: The processes by which neurons degenerate in chronic neurodegenerative diseases remain unclear. Synaptic loss and axonal pathology frequently precede neuronal loss and protein aggregation demonstrably spreads along neuroanatomical pathways in many neurodegenerative diseases. The spread of neur...

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Detalles Bibliográficos
Autores principales: Reis, Renata, Hennessy, Edel, Murray, Caoimhe, Griffin, Éadaoin W., Cunningham, Colm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744702/
https://www.ncbi.nlm.nih.gov/pubmed/25727649
http://dx.doi.org/10.1111/nan.12232