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Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery

AIM: Patient‐reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed to: (i) summarize PROMs in studies of CRC surger...

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Autores principales: McNair, A. G. K., Whistance, R. N., Forsythe, R. O., Rees, J., Jones, J. E., Pullyblank, A. M., Avery, K. N. L., Brookes, S. T., Thomas, M. G., Sylvester, P. A., Russell, A., Oliver, A., Morton, D., Kennedy, R., Jayne, D. G., Huxtable, R., Hackett, R., Dutton, S. J., Coleman, M. G., Card, M., Brown, J., Blazeby, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744711/
https://www.ncbi.nlm.nih.gov/pubmed/26058878
http://dx.doi.org/10.1111/codi.13021
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author McNair, A. G. K.
Whistance, R. N.
Forsythe, R. O.
Rees, J.
Jones, J. E.
Pullyblank, A. M.
Avery, K. N. L.
Brookes, S. T.
Thomas, M. G.
Sylvester, P. A.
Russell, A.
Oliver, A.
Morton, D.
Kennedy, R.
Jayne, D. G.
Huxtable, R.
Hackett, R.
Dutton, S. J.
Coleman, M. G.
Card, M.
Brown, J.
Blazeby, J. M.
author_facet McNair, A. G. K.
Whistance, R. N.
Forsythe, R. O.
Rees, J.
Jones, J. E.
Pullyblank, A. M.
Avery, K. N. L.
Brookes, S. T.
Thomas, M. G.
Sylvester, P. A.
Russell, A.
Oliver, A.
Morton, D.
Kennedy, R.
Jayne, D. G.
Huxtable, R.
Hackett, R.
Dutton, S. J.
Coleman, M. G.
Card, M.
Brown, J.
Blazeby, J. M.
author_sort McNair, A. G. K.
collection PubMed
description AIM: Patient‐reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed to: (i) summarize PROMs in studies of CRC surgery and (ii) categorize PRO content to inform the future development of an agreed minimum ‘core’ outcome set to be measured in all trials. METHOD: All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and the number of items documented. All items were extracted and independently categorized by content by two researchers into ‘health domains’, and discrepancies were discussed with a patient and expert. Domain popularity and the distribution of items were summarized. RESULTS: Fifty‐eight different PROMs were identified from the 104 included studies. There were 23 generic, four cancer‐specific, 11 disease‐specific and 16 symptom‐specific questionnaires, and three ad hoc measures. The most frequently used PROM was the EORTC QLQ‐C30 (50 studies), and most PROMs (n = 40, 69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were ‘anxiety’ (n = 85, 9.2%), ‘fatigue’ (n = 67, 7.3%) and ‘physical function’ (n = 63, 6.9%). No domains were included in all PROMs. CONCLUSION: There is major heterogeneity of PRO measurement and a wide variation in content assessed in the PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials.
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spelling pubmed-47447112016-02-18 Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery McNair, A. G. K. Whistance, R. N. Forsythe, R. O. Rees, J. Jones, J. E. Pullyblank, A. M. Avery, K. N. L. Brookes, S. T. Thomas, M. G. Sylvester, P. A. Russell, A. Oliver, A. Morton, D. Kennedy, R. Jayne, D. G. Huxtable, R. Hackett, R. Dutton, S. J. Coleman, M. G. Card, M. Brown, J. Blazeby, J. M. Colorectal Dis Systematic Review AIM: Patient‐reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed to: (i) summarize PROMs in studies of CRC surgery and (ii) categorize PRO content to inform the future development of an agreed minimum ‘core’ outcome set to be measured in all trials. METHOD: All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and the number of items documented. All items were extracted and independently categorized by content by two researchers into ‘health domains’, and discrepancies were discussed with a patient and expert. Domain popularity and the distribution of items were summarized. RESULTS: Fifty‐eight different PROMs were identified from the 104 included studies. There were 23 generic, four cancer‐specific, 11 disease‐specific and 16 symptom‐specific questionnaires, and three ad hoc measures. The most frequently used PROM was the EORTC QLQ‐C30 (50 studies), and most PROMs (n = 40, 69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were ‘anxiety’ (n = 85, 9.2%), ‘fatigue’ (n = 67, 7.3%) and ‘physical function’ (n = 63, 6.9%). No domains were included in all PROMs. CONCLUSION: There is major heterogeneity of PRO measurement and a wide variation in content assessed in the PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials. John Wiley and Sons Inc. 2015-10-09 2015-11 /pmc/articles/PMC4744711/ /pubmed/26058878 http://dx.doi.org/10.1111/codi.13021 Text en ©2015 The Authors. Colorectal Disease published by John Wiley & Sons Ltd on behalf of Association of Coloproctology of Great Britain and Ireland. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Systematic Review
McNair, A. G. K.
Whistance, R. N.
Forsythe, R. O.
Rees, J.
Jones, J. E.
Pullyblank, A. M.
Avery, K. N. L.
Brookes, S. T.
Thomas, M. G.
Sylvester, P. A.
Russell, A.
Oliver, A.
Morton, D.
Kennedy, R.
Jayne, D. G.
Huxtable, R.
Hackett, R.
Dutton, S. J.
Coleman, M. G.
Card, M.
Brown, J.
Blazeby, J. M.
Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title_full Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title_fullStr Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title_full_unstemmed Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title_short Synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
title_sort synthesis and summary of patient‐reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744711/
https://www.ncbi.nlm.nih.gov/pubmed/26058878
http://dx.doi.org/10.1111/codi.13021
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