Ovarian cancer treatment: The end of empiricism?

The diagnosis, investigation, and management of ovarian cancer are in a state of flux—balancing ever rapid advances in our understanding of its biology with 3 decades of clinical trials. Clinical trials that started with empirically driven selections have evolved in an evidence‐informed manner to gr...

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Detalles Bibliográficos
Autores principales: Lheureux, Stephanie, Karakasis, Katherine, Kohn, Elise C., Oza, Amit M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744728/
https://www.ncbi.nlm.nih.gov/pubmed/26096019
http://dx.doi.org/10.1002/cncr.29481
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author Lheureux, Stephanie
Karakasis, Katherine
Kohn, Elise C.
Oza, Amit M.
author_facet Lheureux, Stephanie
Karakasis, Katherine
Kohn, Elise C.
Oza, Amit M.
author_sort Lheureux, Stephanie
collection PubMed
description The diagnosis, investigation, and management of ovarian cancer are in a state of flux—balancing ever rapid advances in our understanding of its biology with 3 decades of clinical trials. Clinical trials that started with empirically driven selections have evolved in an evidence‐informed manner to gradually improve outcome. Has this improved understanding of the biology and associated calls to action led to appropriate changes in therapy? In this review, the authors discuss incorporating emerging data on biology, combinations, dose, and scheduling of new and existing agents with patient preferences in the management of women with ovarian cancer. Cancer 2015;121:3203–3211. © 2015 American Cancer Society.
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spelling pubmed-47447282016-02-18 Ovarian cancer treatment: The end of empiricism? Lheureux, Stephanie Karakasis, Katherine Kohn, Elise C. Oza, Amit M. Cancer Review Article The diagnosis, investigation, and management of ovarian cancer are in a state of flux—balancing ever rapid advances in our understanding of its biology with 3 decades of clinical trials. Clinical trials that started with empirically driven selections have evolved in an evidence‐informed manner to gradually improve outcome. Has this improved understanding of the biology and associated calls to action led to appropriate changes in therapy? In this review, the authors discuss incorporating emerging data on biology, combinations, dose, and scheduling of new and existing agents with patient preferences in the management of women with ovarian cancer. Cancer 2015;121:3203–3211. © 2015 American Cancer Society. John Wiley and Sons Inc. 2015-06-10 2015-09-15 /pmc/articles/PMC4744728/ /pubmed/26096019 http://dx.doi.org/10.1002/cncr.29481 Text en © 2015 The Authors. American Cancer Society This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/3.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Article
Lheureux, Stephanie
Karakasis, Katherine
Kohn, Elise C.
Oza, Amit M.
Ovarian cancer treatment: The end of empiricism?
title Ovarian cancer treatment: The end of empiricism?
title_full Ovarian cancer treatment: The end of empiricism?
title_fullStr Ovarian cancer treatment: The end of empiricism?
title_full_unstemmed Ovarian cancer treatment: The end of empiricism?
title_short Ovarian cancer treatment: The end of empiricism?
title_sort ovarian cancer treatment: the end of empiricism?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744728/
https://www.ncbi.nlm.nih.gov/pubmed/26096019
http://dx.doi.org/10.1002/cncr.29481
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AT ozaamitm ovariancancertreatmenttheendofempiricism

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