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Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics

Personalized health care (PHC) is an evolving field of medicine aimed at providing the right therapy to the right patient at the right time. This approach often incorporates the use of companion diagnostics (CDx) assays that provide information essential for the safe and effective use of the corresp...

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Detalles Bibliográficos
Autores principales: Batrla, Richard, Jordan, Bruce W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744740/
https://www.ncbi.nlm.nih.gov/pubmed/25866164
http://dx.doi.org/10.1111/nyas.12754
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author Batrla, Richard
Jordan, Bruce W.M.
author_facet Batrla, Richard
Jordan, Bruce W.M.
author_sort Batrla, Richard
collection PubMed
description Personalized health care (PHC) is an evolving field of medicine aimed at providing the right therapy to the right patient at the right time. This approach often incorporates the use of companion diagnostics (CDx) assays that provide information essential for the safe and effective use of the corresponding drug. In addition to oncology, many other therapy areas, such as cardiovascular, neurological, and infectious and inflammatory diseases, may benefit from PHC, owing to disease complexity and heterogeneity. Furthermore, although most U.S. Food and Drug Administration–approved CDx are based on molecular‐based technologies, immunoassays can provide a significant contribution to the evolution of CDx in patient management. In this review we discuss how the incorporation of biomarker immunoassays into routine diagnostic testing may allow early and definitive detection of Alzheimer's disease and enable population enrichment in clinical trials. In addition, we will describe how biomarker‐based CDx immunoassays have potential utility for stratifying patients with asthma based on their potential response to therapy and for selecting treatment according to phenotypic profile. Continued research into the underlying disease pathology and development of accurate and reliable diagnostic assays may ensure that PHC becomes the future standard for many indications.
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spelling pubmed-47447402016-02-18 Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics Batrla, Richard Jordan, Bruce W.M. Ann N Y Acad Sci Original Articles Personalized health care (PHC) is an evolving field of medicine aimed at providing the right therapy to the right patient at the right time. This approach often incorporates the use of companion diagnostics (CDx) assays that provide information essential for the safe and effective use of the corresponding drug. In addition to oncology, many other therapy areas, such as cardiovascular, neurological, and infectious and inflammatory diseases, may benefit from PHC, owing to disease complexity and heterogeneity. Furthermore, although most U.S. Food and Drug Administration–approved CDx are based on molecular‐based technologies, immunoassays can provide a significant contribution to the evolution of CDx in patient management. In this review we discuss how the incorporation of biomarker immunoassays into routine diagnostic testing may allow early and definitive detection of Alzheimer's disease and enable population enrichment in clinical trials. In addition, we will describe how biomarker‐based CDx immunoassays have potential utility for stratifying patients with asthma based on their potential response to therapy and for selecting treatment according to phenotypic profile. Continued research into the underlying disease pathology and development of accurate and reliable diagnostic assays may ensure that PHC becomes the future standard for many indications. John Wiley and Sons Inc. 2015-04-09 2015-06 /pmc/articles/PMC4744740/ /pubmed/25866164 http://dx.doi.org/10.1111/nyas.12754 Text en © 2015 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals Inc. on behalf of The New York Academy of Sciences. This is an open access article under the terms of the Creative Commons Attribution ‐NoDerivs (http://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Original Articles
Batrla, Richard
Jordan, Bruce W.M.
Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title_full Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title_fullStr Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title_full_unstemmed Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title_short Personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
title_sort personalized health care beyond oncology: new indications for immunoassay‐based companion diagnostics
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744740/
https://www.ncbi.nlm.nih.gov/pubmed/25866164
http://dx.doi.org/10.1111/nyas.12754
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