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Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania
Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744759/ https://www.ncbi.nlm.nih.gov/pubmed/26084722 http://dx.doi.org/10.1111/bjh.13553 |
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| author | Makani, Julie Mgaya, Josephine Balandya, Emmanuel Msami, Khadija Soka, Deogratias Cox, Sharon E. Komba, Albert N. Rwezaula, Stella Meda, Elineema Muturi, David Kitundu, Jesse Fegan, Gregory Kirkham, Fenella J. Newton, Charles R. Snow, Robert W. Lowe, Brett |
| author_facet | Makani, Julie Mgaya, Josephine Balandya, Emmanuel Msami, Khadija Soka, Deogratias Cox, Sharon E. Komba, Albert N. Rwezaula, Stella Meda, Elineema Muturi, David Kitundu, Jesse Fegan, Gregory Kirkham, Fenella J. Newton, Charles R. Snow, Robert W. Lowe, Brett |
| author_sort | Makani, Julie |
| collection | PubMed |
| description | Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non‐Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56–0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa. |
| format | Online Article Text |
| id | pubmed-4744759 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-47447592016-02-18 Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania Makani, Julie Mgaya, Josephine Balandya, Emmanuel Msami, Khadija Soka, Deogratias Cox, Sharon E. Komba, Albert N. Rwezaula, Stella Meda, Elineema Muturi, David Kitundu, Jesse Fegan, Gregory Kirkham, Fenella J. Newton, Charles R. Snow, Robert W. Lowe, Brett Br J Haematol Red Cells and Iron Bacteraemia is a leading cause of morbidity in sickle cell anaemia (SCA), but information from studies in Africa is limited. We evaluated 890 admissions from 648 SCA patients at a tertiary hospital in Tanzania. Bacteraemia was present in 43 admissions (4·8%); isolates included Staphylococcus aureus (12/43; 28%), non‐Typhi Salmonella (9/43; 21%), Streptococcus pneumoniae (3/43; 7%) and Salmonella Typhi (2/43; 5%). Compared to SCA patients without bacteraemia, SCA patients with bacteraemia had significantly lower haemoglobin [71 g/l vs. 62 g/l, odds ratio 0·72 (95% confidence interval 0·56–0·91), P < 0·01]. Further exploration is needed of the relationship between anaemia and bacterial infections in SCA in Africa. John Wiley and Sons Inc. 2015-06-17 2015-10 /pmc/articles/PMC4744759/ /pubmed/26084722 http://dx.doi.org/10.1111/bjh.13553 Text en © 2015 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Red Cells and Iron Makani, Julie Mgaya, Josephine Balandya, Emmanuel Msami, Khadija Soka, Deogratias Cox, Sharon E. Komba, Albert N. Rwezaula, Stella Meda, Elineema Muturi, David Kitundu, Jesse Fegan, Gregory Kirkham, Fenella J. Newton, Charles R. Snow, Robert W. Lowe, Brett Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title | Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title_full | Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title_fullStr | Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title_full_unstemmed | Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title_short | Bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in Tanzania |
| title_sort | bacteraemia in sickle cell anaemia is associated with low haemoglobin: a report of 890 admissions to a tertiary hospital in tanzania |
| topic | Red Cells and Iron |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744759/ https://www.ncbi.nlm.nih.gov/pubmed/26084722 http://dx.doi.org/10.1111/bjh.13553 |
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